A Cannabigerol-rich Cannabis Sativa Extract, Devoid Of [INCREMENT]9-tetrahydrocannabinol, Elicits Hyperphagia In Rats

Anorexia and Cachexia

Key Findings

We have recently shown that purified cannabigerol (CBG) is a novel appetite stimulant in rats. As standardized extracts from Cannabis chemotypes dominant in one pCB [botanical drug substances (BDSs)] often show greater efficacy and/or potency than purified pCBs, we investigated the effects of a CBG-rich BDS, devoid of psychoactive [INCREMENT]-tetrahydrocannabinol, on feeding behaviour. Results showed that the total food intake was increased by 120 and 240 mg/kg CBG-BDS (1.53 and 1.36 g, respectively, vs. 0.56 g in vehicle-treated animals). Latency to feeding onset was dose dependently decreased at all doses, and 120 and 240 mg/kg doses increased both the number of meals consumed and the cumulative size of the first two meals. No significant effect was observed on ambulatory activity or rearing behaviour. CBG-BDS is a novel appetite stimulant, which may have greater potency than purified CBG, despite the absence of [INCREMENT]-tetrahydrocannabinol in the extract.

Information and Links


Link: A Cannabigerol-rich Cannabis Sativa Extract, Devoid Of [INCREMENT]9-tetrahydrocannabinol, Elicits Hyperphagia In Rats

Year: 2017

DOI: 10.1097/FBP.0000000000000285


Ratings

(How Ratings Work)

Anorexia and Cachexia — 2


Possible to probable range of efficacy of cannabis for treatment of Anorexia and Cachexia according to the results found in this study.

Drugs Used

CBG-rich botanical drug substance, devoid of THC.